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5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule with the molecular formula C24H26N4O and a molecular weight of approximately 386.49 g/mol[2][1]. It is an experimental drug that has been studied as an inhibitor of dihydrofolate reductase (DHFR), particularly in bacterial systems such as Staphylococcus aureus[8]. The structure features a pyrimidinediamine core substituted with a biphenylyl-butynyl side chain. Its mechanism of action is presumed to involve competitive inhibition at the DHFR active site, thereby interfering with folate metabolism and DNA synthesis in susceptible organisms. There are no known approved clinical indications or marketed products containing this compound; it remains primarily a research tool for studying DHFR inhibition.
- Other names
- 5-[ (3R)-3-(5-methoxy-3',5'-dimethylbiphenyl -3 -yl)but -1 -yn -1 -yl ] -6-methylpyrimidine -2,4-diamine5-[ (3R)-3-[ 3-(3,5-dimethylphenyl )–5-methoxyphenyl ] but –1–yn –1– yl ] –6–methylpyrimidine –2,4–diamine
02
Targets
DHFR (Dihydrofolate reductase)
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